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, Jorge Puelles Galderma , Zug , Switzerland Search for other works by this author on: Oxford Academic Pablo Arija OPEN Health Evidence & Access , Rotterdam , The Netherlands Search for other works by this author on: Oxford Academic Nicholas Durno OPEN Health Evidence & Access , London , UK Search for other works by this author on: Oxford Academic Krystallia Pantiri OPEN Health Evidence & Access , Rotterdam , The Netherlands Search for other works by this author on: Oxford Academic Ramkumar Subramanian Galderma , Zug , Switzerland Search for other works by this author on: Oxford Academic Katrin Jack Galderma , Zug , Switzerland Search for other works by this author on: Oxford Academic Olivier Chambenoit Galderma , Boston, MA , USA Search for other works by this author on: Oxford Academic Marco Boeri OPEN Health Evidence & Access , London , UK Search for other works by this author on: Oxford Academic Ben van Hout OPEN Health Evidence & Access , London , UK Search for other works by this author on: Oxford Academic Jonathan I Silverberg Department of Dermatology, George Washington University School of Medicine and Health Sciences , Washington, DC , USA Search for other works by this author on: Oxford Academic
British Journal of Dermatology, Volume 191, Issue Supplement_2, August 2024, ljae266.065, https://doi.org/10.1093/bjd/ljae266.065
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08 August 2024
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Jorge Puelles, Pablo Arija, Nicholas Durno, Krystallia Pantiri, Ramkumar Subramanian, Katrin Jack, Olivier Chambenoit, Marco Boeri, Ben van Hout, Jonathan I Silverberg, 691 - Understanding patient and physician preferences when choosing between biologic and oral systemic treatment options for moderate-to-severe atopic dermatitis: a discrete choice experiment, British Journal of Dermatology, Volume 191, Issue Supplement_2, August 2024, ljae266.065, https://doi.org/10.1093/bjd/ljae266.065
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Abstract
Background
A growing number of treatment options are becoming available for moderate-to-severe atopic dermatitis (AD), including biologic therapies. As these treatments have different efficacy, safety, and tolerability profiles, it is important to understand patient and physician preferences for informed treatment decision making.
Objective
To discover the importance of different attributes, including efficacy, safety, and mode of administration, and to provide insights into whether patient preferences concur or conflict with those of physicians.
Methods
We conducted a cross-sectional, online discrete choice experiment involving 306 patients with AD and 206 physicians in the UK and Germany. Qualitative interviews identified key attributes influencing treatment preferences, including efficacy (itch relief, sleep disturbance, time-to-itch relief, and total body surface area affected by eczema), safety (special warnings and risks of eye problems and shingles), and treatment administration. Data were analyzed using a random parameters logit model to calculate the conditional relative importance of each attribute.
Results
Both groups placed significant emphasis on efficacy, with reducing sleep disturbance ranking first for patients and second for physicians and itch ranking first for physicians and second for patients. Time to itch relief was the third most important efficacy attribute for both groups, although it was more important for patients. For both groups, the risk of eye problems was the most important safety concern. The mode of administration was not considered of great importance when compared with efficacy and safety attributes.
Conclusions
Our findings suggest patients prioritize sleep disturbance, an attribute not captured in other preference studies in AD, and itch. This emphasizes the importance of addressing sleep-related issues and itching to enhance patients’ well-being. The findings offer insights for prioritization strategies among healthcare providers, aiming to improve patient outcomes amidst a growing number of AD treatments.
atopic dermatitis, itch, sleep disturbance, efficacy
© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
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